About i-colloid

i-colloid, IMRA’s latest product family, brings you efficient and versatile nanoparticle bioconjugation technology.



Colloidal noble metal nanoparticles (particularly gold nanoparticles) are widely used in biomedical research due to their low toxicity and the characteristic optical property known as surface plasmon resonance. Their current and potential biomedical applications include immunostaining, bioassay research, and drug delivery. They are also used as the enhancing agents in optical biosensing techniques such as surface enhanced Raman scattering (SERS) and fluorescence quenching. Conventional synthesis of noble metal nanoparticle colloids is based on chemical reduction of metal salts and stabilization with surfactants.

This photo shows high purity gold nanoparticle colloids provided by IMRA.

i-colloid Production

IMRA takes the novel approach of ultrafast pulsed laser ablation directly in liquid solvents where the ablated material forms a stable colloidal suspension without using stabilizing agents. Our proprietary production method increases the gold nanoparticle surface area available for binding biomolecules and reduces the activation energy required for the binding reaction, therefore provides higher binding efficiency and loading.

Quality Control

IMRA applies strict quality control to maintain high solvent purity, narrow particle size distribution, and batch-to-batch reproducibility. Our i-colloid Au series have been tested under a variety of environmental conditions to ensure consistent colloidal properties and reproducible performances in bioconjugation and other applications. The colloids’ long term stability is also tested for at least 6 months to confirm the enduring mono-dispersion and surface chemistry.

Customer Collaboration in Research

In addition to our dedication to provide high quality noble metal nanoparticle colloids, IMRA is also open to collaboration with academic institutes and industry in developing new nanoparticle-based bioassay and biosensing techniques.